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Waters has launched 1 mm I.D. liquid chromatography (LC) columns with Waters' MaxPeak Premier Technology for its Acquity, BioResolve, and GTxResolve Column brands. Significantly improving sensitivity while minimizing solvent and sample waste, the new microflow columns deliver high-quality results across bioanalysis, pharmaceutical discovery and development, and metabolomics, proteomics and lipidomics – all areas where both sample availability and time are limited.
This launch builds on the company's strong cadence of high-impact chemistry innovation, redefining what is possible in the separation of larger, more complex molecules by exceeding the limits of current technologies.
Rob Carpio, senior vice president, Waters Analytical Sciences, Waters Corporation. S said, “The company continues to invest in the advancement of breakthrough technologies to remove common obstacles for our customers in high-throughput pharmaceutical and biopharmaceutical laboratories, accelerating and simplifying the development of life-changing therapies.
We know that in disciplines such as cell and gene therapy and personalized cancer medicines, sample availability is limited and analyte recovery is critical. Today, we are proud to introduce our new microflow LC columns with MaxPeak Premier Technology that protect these precious assets, while raising the bar on sensitivity, data quality, and reproducibility,” he added.
The new microflow LC columns apply Waters' MaxPeak High Performance Surface (HPS) Technology to a 1 mm I.D. format. This significant advancement minimizes nonspecific adsorption (NSA) and improves recovery for small molecules, peptides, and oligonucleotides. MaxPeak HPS Technology is of particular benefit for those investigating molecules with challenging analyte recovery, such as phosphorylated peptides, by removing analytical barriers and speeding workflows.
"We saw a strong benefit matching, or even exceeding, our analytical sensitivity requirements when switching from 2.1 mm I.D. stainless steel columns to Waters' MaxPeak Premier Technology columns. It's great to have MaxPeak Technology now available in 1 mm I.D. microflow columns. They'll give our metabolomics team the opportunity to save solvent while delivering reproducible, fast, and highly accurate results in high-throughput operations," said Oliver Fiehn, Ph.D., Professor, University of California, Davis.
Using these columns, scientists can consistently expect sharper peaks, enhanced peak capacity, and reduced peak tailing even at low flow rates, along with highly reproducible performance from the very first injection. These benefits significantly reduce the time and variability associated with column passivation in traditional stainless steel column designs. For customers transitioning from 2.1 mm I.D. analytical-scale LC columns to microflow formats, the new 1 mm I.D. columns deliver equivalent or improved sensitivity, while using only one-quarter of the solvent and sample required for analytical flow, helping labs meet their environmental goals while improving analytical performance.
The new 1 mm I.D. columns with Waters' MaxPeak Premier Technology will be available globally beginning February 17, 2026, with immediate shipment.
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